ATGL produces essential signaling molecules needed for regulation of lipid.

Special fats cleaving enzymes, called lipases, are used to remobilize stored fat from cellular depots. One of them, Adipose Triglyceride Lipase , is responsible for the first step in the breakdown of fat. Researchers from the University of Graz and co-workers from several countries statement in the current issue of Nature Medicine that ATGL also produces important signaling molecules that are crucial for the regulation of energy fat burning capacity. Related StoriesDisclosing genetic risk for CHD results in lower low-density lipoprotein cholesterolMayo Clinic investigators discover novel mechanism associated with diabetes riskScreening for asymptomatic atrial fibrillation could decrease risk of stroke, premature deathNormal energy and lipid fat burning capacity requires complex regulation by a network of signaling procedures.Albrecht, Ph.D., and Jean-Pierre Bronowicki, M.D., Ph.D. For the SPRINT-2 Investigators: Boceprevir for Untreated Chronic HCV Genotype 1 Infection Persistent infection with the hepatitis C virus affects more than 170 million people worldwide.3-9 Recent efforts to improve the rate of sustained virologic response have focused on oral direct-acting antiviral agents.10-13 Boceprevir is a linear peptidomimetic ketoamide serine protease inhibitor that binds reversibly to the HCV nonstructural 3 active site. 15,16 In the SPRINT-2 trial, we examined if the addition of boceprevir to regular therapy could enhance the rates of sustained virologic response in previously untreated patients infected with HCV genotype 1.